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Arnie Johnson,
Ph.D.
Professor
Department of Pharmaceutical Sciences
(o) 518.694.7128
johnsona2@acp.edu
Education:
Ph.D., Albany Medical College, Albany, NY
Courses Taught at ACP:
Pharmacology/Medicinal Chemistry I, II, III & IV.
Research Interests:
Dr. Johnson's primary research interest is the study of inflammation-mediated organ dysfunction. His research focuses on two models of organ dysfunction. Dr. Johnson's first and primary interest is the pathogenesis of pulmonary edema, a major cause of death and disability during systemic inflammation and septic shock. Specifically, Dr. Johnson investigates the role of the cytokine, tumor necrosis factor-a, in the pathogenesis of pulmonary edema and lung dysfunction. The effect of tumor necrosis factor-a on the cell cytoskeleton and on reactive oxygen and nitrogen molecules is a focus in Dr. Johnson's laboratory. The second model of organ dysfunction he studies is bladder impairment induced by urethral obstruction, a model of benign prostatic hypertrophy. The two models of organ dysfunction share similar mechanisms of organ injury. An improved understanding of the molecular mechanisms that cause inflammation mediated organ dysfunction will ultimately lead to better treatments for septic shock and other disorders.
Recent Publications:
Agartan CA, Leggett RE, Whitbeck C, Chichester P, Neuman, Johnson A and Levin RM. Role of nitric oxide in the acute response of the rabbit to partial outlet obstruction. Urologia internationalis, in press, 2006.
Neumann PH, Gertzberg N, Vaughan E, Weisbrot J, Woodburn R, Lambert W and Johnson A. Peroxynitrite mediates TNF-induced endothelial barrier dysfunction and nitration of actin. American Journal of Physiology. Lung Cellular and Molecular Physiology 290:L674-L684, 2006.
Conners W, Whitbeck C, Chicester
P, Legget R, Lin A, Johnson A, Kogan B,
Levin R and Mannikarottu A. L-NAME, a nitric oxide synthase inhibitor, diminishes
oxidative
damage in urinary bladder partial outlet obstruction. American Journal
of Physiology. Renal Physiology. 290:F357-F363, 2006.
Huang F, Subbaiah PV, Holian O,
Zhang J, Johnson A, Gertzberg N and Lum H.
Lysophosphatidylcholine increases endothelial permeability: role of PKC and
RhoA cross-talk. The American Journal of Physiology. 289:L176-L185,
2005.
Levin RM, Leggett RE, Agartan CA,
Whitbeck C, Chichester P, Neumann P and
Johnson A. Effect of partial outlet obstruction on nitrotyrosine content and
distribution within
the rabbit bladder. Molecular and Cellular Biochemistry. 276:143-148,
2005.