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William R. Millington, Ph.D.
Professor, Chair
Department of Pharmaceutical Sciences
(o) 518.694.7242
Education:
Ph.D., Massachusetts Institute of Technology
Courses Taught at ACP:
Pharmacology and Medicinal Chemistry III and IV, Physiology/Pathophysiology I
Research Interests:
Opiate analgesics relieve pain by mimicking the central effects of opioid peptides. Our laboratory investigates the anatomy of opioid neurons, the function of opioid peptides they synthesize and the mechanisms that regulate their synthesis. The ultimate goal is to develop novel treatments for adverse effects of opiates, particularly addiction.
Recent Publications:
Göktalay G, Cavun S, Levendusky MC, Hamilton JR, Millington WR. Glycyl-glutamine inhibits nicotine conditioned place preference and withdrawal. Eur J Pharmacol 530:95-102, 2006.
Göktalay G, Cavun S, Levendusky MC, Resch, GE, Veno, PA , Millington WR. Hemorrhage activates proopiomelanocortin neurons in the rat hypothalamus. Brain Res 1070:45-55, 2006.
Millington WR, Göktalay G. Neurochemical approaches to addiction treatment. In: Smith H, Passik S, eds., Textbook, of Pain and Chemical Dependency, Oxford University Press, NY (In Press).
Cavun S, Göktalay G, Millington WR. Glycyl-glutamine, an endogenous ß-endorphin-derived peptide, inhibits morphine conditioned place preference, tolerance, dependence and withdrawal. J Pharmacol Exp Ther 315:949-958, 2005.
Cavun S, Göktalay G, Millington WR. The hypotension evoked by visceral nociception is mediated by delta opioid receptors in the periaqueductal gray. Brain Res 1019:237-245, 2004.