Faculty-Chikhale

Prashant J. Chikhale, Ph.D.

Associate Professor
Department of Pharmaceutical Sciences

Education:

Ph.D., University of Florida, Gainesville

Courses Taught at ACP:
Pharmaceutics I
Pharmaceutics II
Pharmaceutical & Bioanalytical Techniques
Seminar II

Research Interests:
Drug targeting and delivery particularly across the BBB and oral absorption; Anticancer drug development and formulations research; Bioanalysis particularly using HPLC, MS and bioimaging tools

Recent Publications:
Weerapreyakul N, Hollenbeck RG and Chikhale PJ. Stability of bioreductive drug delivery systems containing melphalan is influenced by conformational constraint and electronic properties of substituents. Bioorg. Med. Chem. Lett., 10:2391-2395 (2000).

Killian DM and Chikhale PJ. A bioreversible prodrug approach designed to shift mechanism of brain uptake for amino acid-containing anticancer agents. J. Neurochem., 76:966-974 (2001).

Gharat L, Taneja R, Weerapreeyakul N, Rege B, Polli J and Chikhale PJ. Targeted Drug Delivery Systems 6: Intracellular bioreductive activation, uptake and transport of an anticancer drug delivery system across intestinal Caco-2 cell monolayers. Int. J. Pharm., 219:1-10 (2001).

Killian DM and Chikhale PJ. Predominant functional activity of the large, neutral amino acid transporter (LAT1) isoform at the cerebrovasculature. Neurosci. Lett., 306:1-4 (2001).

Rautio J and Chikhale PJ. Drug delivery systems for brain tumor therapy. Current Pharmaceutical Design, 10:1341-1353 (2004).

Killian DM, Hermeling S and Chikhale PJ. Targeting the cerebrovascular large neutral amino acid transporter (LAT1) isoform using a novel disulfide-based brain drug delivery system. Drug Delivery, in press, (2006).

Grants Obtained:
R15CA74377 Chikhale (PI), 7/1/99 - 6/30/02, NIH/NCI
Redox-Based Prodrugs for Solid Tumor Targeting
The major goal of this project was to determine bioreductive properties of antitumor prodrugs
Role: PI

2002-AFPE Scholar, AFPE Fellow & Pharmacy Faculty New Investigator Awards, American Foundation for Pharmaceutical Education

Maryland Industrial Partnership Grant, Burstein (PI), 6/1/97 - 5/31/99
University of Maryland-In Vitro Cell Systems, Inc.
Dynamic In Vitro Model of the Blood-Brain Barrier (BBB)
The major goal of this project was to determine potential of a capillary, flow-through model of the BBB
Role: Co-Principal Investigator

American Association of Colleges of Pharmacy (AACP)-New Investigator Grant
AACP, Chikhale (PI), 7/1/96 - 6/30/97
Bioreductive Antitumor Prodrug Delivery Systems
The major goal of this project was to determine reductive and bioreductive potential of antitumor prodrugs

American Cancer Society-University of Maryland-Institutional Grant , ACS
Chikhale (PI), 2/1/95 - 1/31/96
Hypoxia-Selective Prodrugs of Acivicin
The major goal of this project was to determine hypoxia-mediated activation of prodrugs of acivicin

PhRMA Foundation Postdoctoral Fellowship Award, Chikhale (PI), 1/1/92 - 12/31/93
Redox-based prodrugs for decreasing neurotoxicity of acivicin